Stress is a major factory in causing anovulatory cycles. Lack of progesterone production interferes with adrenal production by which one normally responds to stress. To prevent anovulatory cycles normal levels of progesteorne must be maintained in the woman’s blood stream.

Brain registers stress as a threat by evaluating relevant information that’s available; this initial information is amplified with emotional arousal and instantaneous heightening of all senses. Like the internal flashing of a red-alert warning light, increasing the intensity of existing PMS symptoms and causing others symptoms to on-set.

Acute stress sparks the release of adrenaline, raising blood pressure, and increasing blood sugar levels to deal with perceived threat. These physiological changes increase the intensity of existing PMS symptoms and cause the onset of other symptoms.

When woman are under stress the adrenal gland produces cortisol. Cortisol is antagonistic to progesterone; coritsol counter-acts the positive effects of progesterone, which leads to adrenal exhaustion and symptoms of chronic fatigue, while increasing estrogen dominance. To counter-act the negative effects of estrogen dominance women need to take natural progesterone.